AMADEus Seminar - Dr. Sofia Dembski - Thursday 27 october 2016 - 10:00 am ICMCB (Amphi)le 27/10 de 10h à 11h
Fraunhofer Institute for Silicate Research, Neunerplatz 2, 97082 Wuerzburg, Germany
Translational Center Wuerzburg “Regenerative therapies in oncology and musculoskeletal diseases”, Roentgenring 11, 97070 Wuerzburg, Germany
Multifunctional Nanoparticles for Medical Applications
Abstract: The main field of operation of the competence team Theranostics at the Fraunhofer Institute for Silicate Research ISC are products enabling highly efficient and personalized therapies which are accompanied by in vitro and in vivo diagnosis or even combine diagnosis and therapy in situ. This happens in close cooperation with the Translational Center Wuerzburg “Regenerative therapies in oncology and musculoskeletal diseases”,
Well-tailored multifunctional nanoparticles (NPs), which are in the focus of our R&D work, play a major role in the development of future-oriented, advanced functional materials for life science applications such as in contrast agents for medical imaging, for in vitro and in vivo diagnostics, in drug delivery as well as in tissue engineering. Inorganic-organic biohybrid NPs in particular are considered to be important for the development of smart materials and novel technologies for medical applications.
We prepare our NPs by wet-chemical methods: sol-gel, precipitation or hydrothermal synthesis. Our preferred particle materials are inorganic and hybrid materials e.g. materials based on silicate, calcium fluoride and phosphate, TiO2 and iron oxide. To ensure multifunctionality, different approaches are made: the labelling of NP matrix with organic dyes or lanthanoid ions as well as the combination of various materials by core-shell NP design. The resulting NPs are subsequently modified with various chemical functionalities and biological moieties using conventional functionalization and bioconjugation methods. The great potential of newly developed NPs as assay labels for immunodetection, as contrast agents for medical imaging or as tools for tumor therapy is demonstrated in the different projects.